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Modulating the Senescence-Associated Secretory Phenotype (SASP) in Post-Mitotic Neurons Using CRISPRi Targeted to Telomeric Damage Responsive Pathways
Original Research | 2026 | Volume-3 | Issue-2 | Page 78-89 Dr. Manoj Kumar, Tutor, Department of Physiology, JHMC, WB. Dr. Shahan Layek, Independent Researcher, West Bengal, India, Email: layekcallmeshahan@gmail.com Abstract Background Cellular senescence is increasingly recognized as a key contributor to aging and age-related neurodegenerative disorders. Although post-mitotic neurons do not undergo classical replicative senescence, accumulating evidence suggests that persist
Circulating Exosomal MicroRNAs and Metabolomic Profiling as Predictive Biomarkers for Therapeutic Response in Type 2 Diabetes Mellitus
Original Research | 2026 | Volume 3 | Issue 3 | Page 55-64 1. Dr. Shahan Layek, Independent Researcher, West Bengal, India, 2. Dr. Manoj Kumar, Tutor, Department Physiology, JHMC, WB Abstract Background: Type 2 Diabetes Mellitus (T2DM) is a complex metabolic disorder characterized by insulin resistance, impaired glucose homeostasis, and heterogeneous responses to therapeutic interventions. Identifying reliable biomarkers capable of predicting treatment outcomes remains a majo
Hemodynamic Stress and Barrier Integrity: How the Circle of Willis Minimizes Pulsatile Strain on the Blood-Brain Barrier
Original Research | 2026 | Volume 3 | Issue 3 | Page 49-54 1. Dr. Shahan Layek, Independent Researcher, West Bengal, India. 2. Dr. Manoj Kumar, Tutor, Department of Physiology, JHMC, WB. ABSTRACT BACKGROUND: The blood-brain barrier (BBB) is an exquisitely sensitive interface that requires a stable microenvironment to maintain neurological homeostasis. While the Circle of Willis (CoW) is classically recognized for its role in collateral circulation, its function as a hemodynam
Comparative Analysis of Ultrasound-Guided vs. Anatomical Landmark Techniques for Arterial Cannulation by Anaesthesia Technologists in Critical Care
Original Research | 2026 | Volume 3 | Issue 2 | Page 23-27 SUMIT, PhD (Pursuing), MSC, BSC in OTAT, assistant professor, department of Anaesthesia, JNU Medical College Jaipur Rajasthan ABSTRACT BACKGROUND: Arterial cannulation is a vital procedure in critical care for continuous hemodynamic monitoring and frequent blood sampling. While the anatomical landmark technique has been the traditional standard, ultrasound-guided (USG) cannulation is increasingly recognized for its po
Efficacy of Advanced Video Laryngoscopy vs. Direct Laryngoscopy When Managed by Anaesthesia Technologists in Anticipated Difficult Airway Scenarios
Original Research | 2026 | Volume 3 | Issue 3 | Page 44-48 SUMIT, PhD (Pursuing) MSC, BSC in OTAT, Assistant Professor, Department of Anaesthesia, JNU medical College Jaipur Rajasthan Virender, MSc BSc OTAT, Assistant professor, Department of Anaesthesia JNU medical College Jaipur Rajasthan Corresponding Author: Virender, MSc BSc OTAT, Assistant professor, Department of Anaesthesia JNU medical College Jaipur, Rajasthan ABSTRACT BACKGROUND: Tracheal intubation remains a corner
Synergistic Effects of iPSC-Derived Neural Progenitor Cells and Localized Hypothermia on Blood-Spinal Cord Barrier (BSCB) Repair
Original Research | 2026 | Volume 3 | Issue 3 | Page 38-43 Dr. Shahan Layek, Independent Researcher, West Bengal, India, Email: layekcallmeshahan@gmail.com ABSTRACT The disruption of the blood-spinal cord barrier (BSCB) represents a major pathological hurdle in the treatment of spinal cord injury (SCI), serving as a primary gateway for secondary cascades of neuroinflammation, edema, and neuronal apoptosis. Traditional therapies often struggle to provide long-term stabilizatio
Overcoming PROTAC Resistance: Identifying Structural and Genomic Predictors of Efficacy in Next-Generation Targeted Protein Degraders for Hard-to-Treat Cancers
Original Research | 2026 | Volume 3 | Issue 4 | Page 34-39 Dr. Shahan Layek, Independent Researcher, West Bengal, India, Email: layekcallmeshahan@gmail.com Abstract: Proteolysis-Targeting Chimeras (PROTACs) have emerged as a revolutionary modality in chemical biology, offering the ability to degrade "undruggable" proteins by hijacking the cell's ubiquitin-proteasome system. Despite their clinical promise, the acquisition of resistance—arising from mutations in the degradation
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